- Trial site for SLATE – Stereotactic Laser Ablation for Temporal Lobe Epilepsy
- Combining intracranial electrophysiological recording and imaging to develop biomarkers for hippocampal epilepsy
- Development and testing of a cortical visual prosthesis (a multi-institutional collaboration led by V. Leo Towle PhD)
- Understanding the deep brain circuits involved in attention and memory (collaboration with the Departments of Neurobiology and Psychology)
- Investigating genetic susceptibilities in primary generalized epilepsy (collaboration with the Department of Neurobiology)
- Using neurophysiological recordings and mathematical analysis to better understand how central motor systems coordinate limb movement
- Understanding the role of seizures in the pathophysiology of neurocysticercosis
- Understanding and preventing SUDEP
- BOOST III Trial: phase III RCT to evaluate outcome with PbtO2 directed therapy vs. ICP directed therapy in severe TBI
- MISTIE III: Minimally Invasive Surgery Plus rt-PA for intracerebral Hemorrhage Evacuation is a phase III RCT evaluating outcome in patients with ICH treated with catheter directed lytic therapy
- CLEAR III: Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III
- Penetrating traumatic brain injury
- Prognosis after cardiac arrest
- Stroke code activation demographics
- Neurologic complications of ventricular assist devices
- A Double-Blind, Randomized, Multicenter, Placebo Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Fingolimod 0.5 mg Administered Orally Once Daily Versus Placebo in Patients with Chronic Inflammatory
- Demyelinating Polyradiculoneuropathy
- Assessment of intermuscular coherence as a biomarker for ALS and commercialization of a diagnostic test for ALS
- SOD1 designed ankyrin repeat protiens (DARPins), a genetically engineered antibody mimetic protein, as a treatment for ALS
- Unconventional translation of the expanded repeat of a gene, C9ORF72
- Targeting the integrated stress response in ALS
- Studies of Theiler’s virus-induced immune mediated demyelinating disease, a model of MS
- ACTIsSIMA: Double-Blind, controlled phase IIB study of Modified Stem Cells (SB623) in the treatment of motor deficits in ischemic stroke
- CREST-II: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
- RESPECT-ESUS: A randomized, double-blind evaluation in secondary stroke prevention comparing the efficacy and safety of the thrombin inhibitor dabigatran etexilate vs acetylsalicylic acid in patients with embolic stroke of underdetermined source (ESUS)