Research

2020 Translational Neuroscience of Autism

Chicago Symposium on Translational Neuroscience

THE 2020 SYMPOSIUM HAS BEEN POSTPONED

at the Knapp Center for Biomedical Discovery (KCBD)

1st Floor Atrium / Auditorium

900 E. 57th St., Chicago, IL 60637

 

  • The Sophy Hotel is one of Hyde Park's newest luxury hotels and is only 1.0 miles from the symposium location. Call 773-289-1003 for reservations. Ask if the University of Chicago rate is available.
  • The Hyde Park Hyatt is 1.2 miles from the symposium location. Call 773-752-5300 for reservations. Ask if the University of Chicago rate is available.
  • If you are interested in presenting a poster at the symposium, please email the symposium administrator at mscofiel@uchicago.edu no later than April 15, 2020.
  • There is no charge for the poster boards.
  • Poster viewing will begin with breakfast at 9:00 a.m. Please plan to have your poster available for viewing through the lunch hour, ending no sooner than 1:00 p.m.
  • Email the Symposium Administrator at mscofiel@uchicago.edu if you wish to have your name/email added to our mailing list for future symposium notifications.
  • On-site check-in begins at 8:45 a.m.
  • A hot breakfast will be catered from 9:00 a.m. to 9:45a.m.
  • Posters will be on display in the atrium of the KCBD during the breakfast hour.

Christopher M. Gomez, MD PhD

Albina Y. Surbis Professor of Neurology
Professor of Grossman Institute for Neuroscience
of "Committee on Genetics, Genomics and Systems Biology"

Each spring The University of Chicago hosts an annual one-day Symposium on Translational Neuroscience organized by the Department of Neurology and the Neuroscience Institute. As the Symposium Director, Christopher M. Gomez M.D. Ph.D. works with a Steering Committee to select a hot topic in neuroscience and also to choose speakers who are pioneering work in their field on the chosen topic.

  • Introductions will begin at 9:45a.m.

Matthew State M.D. Ph.D.

Professor & Chair, Psychiatry UCSF Weill Institute for Neurosciences

Matthew W. State MD, PhD, is a child psychiatrist and human geneticist studying pediatric neuropsychiatric syndromes. His lab focuses on gene discovery as a launching point for efforts to illuminate the biology of these conditions and to develop novel and more effective therapies.

  • Dr. State's talk is scheduled to begin at 10:15 a.m.
  • Each talk is 30 minutes in length followed by a 15 minute Q&A session. Speaker order is subject to change.

Christopher A. Walsh M.D. Ph.D.

Chief, Division of Genetics and the Bullar Professor of Pediatrics and Neurology, Harvard Medical School

Dr. Walsh’s research focuses on the development, evolution, and function of the human cerebral cortex, including analysis of human genetic diseases that disrupt the structure and function of the cortex. His laboratory has identified genetic causes for more than two-dozen brain diseases of children, associated with autism, intellectual disability, seizures, and cerebral palsy, and has discovered that some of these disease genes were targets of the evolutionary processes that shaped the human brain. Recent work has focused on somatic mutations in the brain, which are present in some brain cells, but not shared by all brain cells, because they occur after fertilization, during the mitotic divisions that generate the brain. The lab has developed methods for analyzing the entire genome of single cells, and has applied that to the systematic analysis of the extent to which the genome of one neuron differs from that of another neuron.

  • Dr. Walsh's talk is scheduled to begin at 11:00 a.m.
  • Each talk is 30 minutes in length followed by a 15 minute Q&A session. Speaker order is subject to change.

  • Enjoy a 15 minute break in the atrium beginning at 11:45 a.m.
  • Lunch will be catered from 12:00 p.m. to 1:00 p.m.
  • Posters will be on display in the atrium of the William Eckhardt Research Center during the lunch hour.

Daniel Geschwind M.D. Ph.D.

Director, Center for Autism Research and Treatment (CART)

Dr. Daniel Geschwind is the Gordon and Virginia MacDonald Distinguished Professor of neurology, psychiatry and human genetics at the UCLA School of Medicine, and the Senior Associate Dean and Associate Vice Chancellor of Precision Medicine at UCLA. Dr. Geschwind obtained his M.D./Ph.D (neurobiology) at Yale School of Medicine (AOA) and completed his internship, residency (Neurology), and postdoctoral fellowship at UCLA, joining the faculty in 1997. Dr. Geschwind’s laboratory takes a system biology approach, integrating genetic, genomic and bio-informatic approaches with basic neurobiological investigation in model systems and human brain. The over-arching goal of these efforts is to develop new therapeutics for nervous system disorders for which disease-altering therapies are not currently available, including autism and neurodegenerative disorders. He serves on the editorial boards of several journals including Cell, Current Opinion in Genetics & Development, Neuron and Science and has published over 450 manuscripts. Dr. Geschwind is also a strong advocate for data and biomaterial sharing, having provided scientific oversight for the Autism Genetic Resource Exchange (AGRE), and is an elected member of the American Academy of Physicians and the National Academy of Medicine, USA.

  • Dr. Geschwind's talk is scheduled to begin at 1:00 p.m.
  • Each talk is 30 minutes in length followed by a 15 minute Q&A session. Speaker order is subject to change.

Richard L. Huganir Ph.D.

Professor & Director, Department of Neuroscience

Dr. Richard Huganir is a professor of neuroscience, biological chemistry and pharmacology and molecular science at the Johns Hopkins University School of Medicine. Dr. Huganir’s research focuses on molecular mechanisms that modulate the communication between neurons in the brain.

He serves as the director of the Solomon H. Snyder Department of Neuroscience at the Johns Hopkins University School of Medicine.

Dr. Huganir and his team focus their efforts on researching the mechanisms that underlie the regulation of the glutamate receptors, the major excitatory neurotransmitter receptors in the brain. These receptors are neurotransmitter-dependent ion channels that allow ions to pass through the neuronal cell membrane, resulting in the excitation of neuronal activity.

  • Dr. Huganir's talk is scheduled to begin at 1:45 p.m.
  • Each talk is 30 minutes in length followed by a 15 minute Q&A session. Speaker order is subject to change.
  • Enjoy a 15 minute break in the atrium beginning at 2:30 p.m.
  • The group photo will also be taken during the break.

Kimberly Huber Ph.D.

Southwestern Medical Foundation Scholar in Medical Research

Research in the Huber lab is focused on understanding the cellular and molecular mechanisms of synapse and neural circuit development and plasticity as well as the role of genes implicated in human autism and intellectual disability in these processes.  To address these questions her lab utilizes state-of-the-art neurophysiology, imaging, biochemistry and molecular biology techniques in mice.  Her lab has discovered novel molecular mechanisms of synaptic plasticity as well as new functions and mechanisms for the Fragile X Mental Retardation gene 1 (Fmr1) in cortical synapse development and plasticity. Her work has led to a better understanding of the neurobiology of Fragile X Syndrome and autism as well as identified novel therapeutic strategies. 

  • Dr. Huber's talk is scheduled to begin at 3:00 p.m.
  • Each talk is 30 minutes in length followed by a 15 minute Q&A session. Speaker order is subject to change.

Thomas Südhof M.D.

Professor of Neurology and of Psychiatry and Behavioral Sciences

Thomas Christian Südhof was born in Göttingen, Germany, on Dec. 22 in 1955, obtained his M.D. and doctoral degrees from the University of Göttingen in 1982. He performed his doctoral thesis work at the Max-Planck-Institut für biophysikalische Chemie in Göttingen with Prof. Victor P. Whittaker on the biophysical structure of secretory granules. From 1983-1986, Südhof trained as a postdoctoral fellow with Drs. Mike Brown and Joe Goldstein at UT Southwestern in Dallas, TX, and elucidated the structure, expression and cholesterol-dependent regulation of the LDL receptor gene. Südhof began his independent career as an assistant professor at UT Southwestern in 1986. When Südhof started his laboratory, he decided to switch from cholesterol metabolism to neuroscience, and to pursue a molecular characterization of synaptic transmission. His work initially focused on the mechanism of neurotransmitter release which is the first step in synaptic transmission, and whose molecular basis was completely unknown in 1986. Later on, Südhof's work increasingly turned to the analysis of synapse formation and specification, processes that mediate the initial assembly of synapses, regulate their maintenance and elimination, and determine their properties. Südhof served on the faculty of UT Southwestern in Dallas until 2008, and among others was the founding chair of the Department of Neuroscience at that institution. In 2008, Südhof moved to Stanford, and became the Avram Goldstein Professor in the School of Medicine at Stanford University. In addition, Südhof has been an Investigator of the Howard Hughes Medical Institute since 1986.

  • Dr. Südhof's talk is scheduled to begin at 3:45 p.m.
  • Each talk is 30 minutes in length followed by a 15 minute Q&A session. Speaker order is subject to change.
  • The 2020 Translational Neuroscience of Autism Symposium will conclude at 4:30 p.m.

Christopher M. Gomez, MD PhD

Albina Y. Surbis Professor of Neurology
Professor of Grossman Institute for Neuroscience
of "Committee on Genetics, Genomics and Systems Biology"

 

Edwin H. Cook Jr. M.D.

Earl M Bane Professor of Psychiatry; Director, Program for Neurodevelopmental Disorders; Director, Division of Child and Adolescent Psychiatry

 

Christian R. Hansel, PhD

Professor of Neurobiology
Professor of Grossman Institute for Neuroscience
of Committee on Computational Neuroscience

 

Xiaochang Zhang, PhD

Assistant Professor of Human Genetics
Assistant Professor of Grossman Institute for Neuroscience
of "Committee on Genetics, Genomics and Systems Biology"

 

  • The Structure and Function of the CB1 Cannabinoid Receptor: Alexandros Makriyannis Ph.D., Northeastern University
  • Molecular Mechanisms of Endocannabinoid-Mediated Plasticity: Pablo Castillo M.D., Ph.D., Albert Einstein
  • The Endocannabinoid System As A Target For Therapeutic Drugs: Daniele Piomelli Ph.D., UC, Irvine
  • Endocannabinoid Roles in Habitual Behavior and Drug Use Disorders: David Lovinger Ph.D., National Institutes of Health
  • Harnessing Cannabis Biology to Advance Treatment of Stress-Related Psychiatric Disorders: Sachin Patel M.D., Vanderbilt University
  • Brain CB2 Receptors and Regulation of Neuroinflammation: Cecilia Hillard Ph.D., Medical College of Wisconsin (The Eileen S. Trafimow Keynote Speaker)
  • Overview: Gut-Brain Axis: Jack Gilbert PhD, University of Chicago
  • The Gut Microbiome and Neuroinflammation: Evidence from Multiple Sclerosis and EAE: Sergio Baranzini PhD, UCSF
  • Harvesting from the Gut Microbiome: The Role of Gut Symbionts in CNS Regulation: Lloyd Kasper M.D., Dartmouth College
  • Role of the Microbiome in Modulation of Amyloid Deposition and Neuroinflammation in Mouse Models of Abeta Amyloidosis: Sangram Sisodia Ph.D., University of Chicago (The Eileen S. Trafimow Keynote Speaker)
  • Microbiota Triggered Neuro-Inflammation and Dopamine Loss in Parkinson Disease: Ali Keshavarzian M.D., Rush University
  • Low-Dose Penicillin Exposure in Adolescent Mice: Implications for Psychiatric Disease: Karen McVey Neufeld Ph.D., McMaster University, Canada
  • Short Chain Fatty Acids: Microbial Modulators of Metabolism, Mitochondria and Mind-Implications in Autism: Derrick MacFabe M.D., Maastricht University, The Netherlands
  • Role of the Microbiome in Cerebral Cavernous Malformation: Mark Kahn M.D., University of Pennsylvania (The Safadi Lecturer)
  • Brain-Machine Interfaces Using Neural Activity from the Posterior Parietal Cortex of Tetraplegic Humans: Richard A. Andersen Ph.D., Caltech (The Eileen S. Trafimow Keynote Speaker)
  • An Implantable Neural Prosthesis for Human Memory: Theodore W. Berger Ph.D., University of Southern California:
  • Closed Loop Neuromodulation for Parkinson’s Disease, the Present and the Future: Helen M. Bronte-Stewart M.D., Stanford University
  • Somatosensation in Human Brain Machine Interfaces: Robert Gaunt Ph.D., University of Pittsburgh:
  • Restoring Movement and User Control of the Paralyzed Arm: BCI-Commanded FES: Robert F. Kirsch Ph.D., Case Western Reserve University
  • The Role of the Thalamus in Parkinsonism: Thomas Wichmann M.D., Emory University
  • Electrical Signaling at Atomic Resolution: From Structure to Therapy: William A. Catterall Ph.D., University of Washington
  • Visualizing the Holy Grail of Sodium Channel Pharmacology: NAv1.7 and Beyond: Jian Payandeh Ph.D., Genentech, Inc.
  • Clinical, Genetic, and Psysiological Characterization of Episodic Neurological Disorders: Louis J. Ptáček M.D., UCSF
  • De novo, Gain-of-Function Mutations of Sodium Channel SCN8A in Epileptic Encephalopathy: Miriam H. Meisler Ph.D., University of Michigan
  • Mechanism-Based Therapeutics in Periodic Paralysis: Steve Cannon M.D. Ph.D., Baylor College of Medicine
  • Mutant Ion Channels, Killer Waves, and Sudden Unexpected Death: Jeffrey L. Noebels M.D., Ph.D.
  • Imaging and Modeling the Functional, Structural, Connectional and Architectonic Properties of the Human Brain: Bruce Fischl Ph.D., Massachusetts General Hospital
  • MRI of Lesion Development and Repair in Multiple Sclerosis: Daniel S.Reich M.D., Ph.D., National Institute of Neurological Disorders and Stroke
  • Biomarkers in Movement Disorders: From Distinct Clinical Nosology to Heterogeneous Symptomatology and Pathologies: Nicolaas Ida Bohnen M.D., University of Michigan
  • Developing a Translational Toolbox – Imaging Parkinson Disease: Kenneth Marek M.D., Institute for Neurodegenerative Disorders
  • Multimodal Imaging Biomarkers in Dementia with Lewy Bodies: Kejal Kantarci M.D., Mayo Clinic
  • Imaging Protein Aggregation in Aging and Dementia: William Jagust M.D., UC Berkeley
  • RNA-Binding Proteins with Prion-Like Domains in Neurodegenerative Diseases: Aaron Gitler Ph.D., Stanford University
  • Regulation of Organismal Proteostasis by Trans-Cellular Chaperone Signaling: Laura Ranum Ph.D., University of Florida
  • Unconventional Translation at CGG Repeats: Mechanisms, Meanings and Roles in Disease Pathogenesis: Peter Todd M.D. Ph.D., University of Michigan
  • RNA as a Therapeutic Target in Myotonic Dystrophy: Charles Thornton M.D., University of Rochester
  • Antisense Splicing Modulation for Therapy and Modeling of CNS Disease: Adrian Krainer Ph.D., Cold Spring Harbor Laboratory
  • Targeted Degradation of Sense and Antisense C9orf72 Transcripts as Therapy for ALS and FTD: Clotilde Lagier-Tourenne M.D., Ph.D., UCSD
  • A Molecular View of the Early Stages of Polypeptide Misfolding and Aggregation: Juan J. de Pablo Ph.D., University of Chicago
  • Regulation of Organismal Proteostasis by Trans-Cellular Chaperone Signaling: Richard I. Morimoto Ph.D., Northwestern University
  • Polymorphism of ss-Amyloid Aggregates: Stephen C. Meredith M.D. Ph.D., University of Chicago
  • The Unfolded Protein Response and ALS: Raymond P. Roos M.D., University of Chicago
  • Activation of Neuronal Kinases and Neurodegeneration in Alzheimer’s Disease: Scott T. Brady Ph.D., University of Illinois at Chicago
  • From Yeast Cells to Patient Neurons: A Powerful Discovery Platform for Parkinson’s and Alzheimer’s Disease: Susan L. Lindquist Ph.D., Massachusetts Institute of Technology
  • Cellular and Molecular Regulation of Blood-Brain Barrier Development: Richard Daneman Ph.D., UCSF
  • Human Blood-Brain Barrier Models Derived from Stem Cell Sources: Eric Shusta Ph.D., University of Wisconsin
  • Immune Mechanisms of Leukocyte Recruitment across the BBB: Alexandre Prat M.D., Ph.D., University of Montreal, Canada
  • Are Epileptic Seizures a BBB Disorder?: Damir Janigro Ph.D., Cleveland Clinic
  • Ultrasound-Induced Blood-Brain Barrier Opening and Drug Delivery in Vivo: Elisa E. Konofagou Ph.D., Columbia University
  • Boosting Blood-Brain Barrier Transport of Biologies: Ryan Watts M.D., Genetech, Inc.
  • Glial Modulation of Sleep, Epilepsy and Depression: Philip Haydon Ph.D., Tufts University
  • Control of Central Nervous System Synapse Formation by Astrocytes: Cagla Eroglu Ph.D., Duke University
  • Glia in Motor Neuron Disease Pathogenesis: The Many Players in Lou Gehrig's Disease: Raymond P.  Roos M.D., University of Chicago
  • Glia Support of Axon Function - Implication for Disease: Klaus-Armin Nave Ph.D., Max Planck Institute of Experimental Medicine, Germany
  • Protein Acetylation in Brain Development and Disease: Patrizia Casaccia M.D., Ph.D., Mount Sinai
  • The Impact of Neuronal/Glial Metabolism on Axonal Degeneration: Jeffrey Milbrandt M.D., Ph.D., Washington University

in conjunction with the 3rd Annual Ataxia Investigator's Meeting

Cerebellar Function (and Episodic) Dysfunction

  • Joanna C. Jen M.D. Ph.D., UCLA
  • Ellen Hess Ph.D., Emory University
  • Kamran Khodakhah Ph.D., Albert Einstein
  • Christian Hansel Ph.D., University of Chicago (keynote speaker)

Molecular Pathogenesis of Recessively Inherited Ataxias

  • Karl Herrup Ph.D., Rutgers University
  • Martin Lavin Ph.D., Queensland Institute of Medical Research, Australia
  • Michael Koenig M.D. Ph.D., Universite Louis-Pasteur, Franc
  • Robert Wilson M.D. Ph.D., University of Pennsylvania
  • Grazia Isaya M.D. Ph.D., Mayo Clinic of Rochester
  • Massimo Pandolfo M.D., Service de Neurologie Hospital Erasme, Belgium
  • Keith Caldecott Ph.D., University of Sussex, United Kingdom (keynote speaker)

Molecular Pathogenesis of Autosomal Dominant Ataxias

  • Stefan Pulst M.D., University of Utah
  • Henry Paulson M.D. Ph.D., University of Michigan
  • Christopher M. Gomez M.D. Ph.D., University of Chicago
  • Albert LaSpada M.D. Ph.D., UCSD
  • Xiao-Jiang Li M.D. Ph.D., Emory University
  • Laura Ranum Ph.D., University of Minnesota
  • Tetsuo Ashizawa M.D. Ph.D., University of Florida
  • Norio Sakai M.D. Ph.D., Hiroshima University, Japan
  • Harry Orr Ph.D., University of Minnesota
  • Richard Moriomoto Ph.D., Northwestern University (keynote speaker)

Moving Towards Therapy: Novel Strategies and Outcomes Measures in Ataxia

  • Sidney Hecht Ph.D., Arizona State University
  • Joel Gottesfeld Ph.D., Scripps Institute
  • Thomas Klockgether M.D., University of Bonn, Germany
  • Ana Solodkin Ph.D., University of Chicago
  • Gulin Oz Ph.D., University of Minnesota
  • Kurt Fischbeck, M.D., NINDS/NIH
  • Ole Isacson M.D., Harvard University (keynote speaker)
  • Beverly Davidson Ph.D., University of Iowa
  • Kenneth Fischbeck M.D., National Institute of Neurological Disorders and Stroke
  • Richard I. Morimoto Ph.D., Northwestern University
  • Evan Snyder M.D., Ph.D., Burnham Institute for Medical Research
  • Robert Vasser, Ph.D., Northwestern University

Novel Insights Into Disease Pathogenesis

  • Marie T. Filbin Ph.D., Hunter College
  • Steven Findbeiner M.D. Ph.D., UCSF
  • James O. McNamara M.D., Duke University

Novel Approaches to Mollecular and Cellular Therapies

  • Timothy Miller M.D. Ph.D., Washington University
  • Steven M. Paul M.D., Lilly Research Laboratories
  • Mark H. Tuszynski M.D. Ph.D., UCSD

Novel Approaches to Bioengineering Therapies

  • Nicho Hatsopoulos Ph.D. University of Chicago
  • Eberhard E. Fetz Ph.D., University of Washington
  • Mahlon R. DeLong M.D. Emory University