People

Richard Kraig, MD PhD

Dr. Richard Kraig is an expert in migraine patient care, migraine research and cerebrovascular disease research. His clinical interests focus on the diagnosis and treatment of migraine headaches. He oversees the Cerebrovascular Disease and Aging Laboratories, which focus on migraine, stroke, epilepsy and cognitive decline from aging.



An active researcher, Dr. Kraig leads investigations to determine how physical, mental and social activities can lessen the impact of neurological disease. Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease. Dr. Kraig's research helps him to develop individualized treatment plans for patients in the Migraine Headache Clinic. He is also involved in teaching medical students, graduate students and residents.

Cornell Medical College
NY
Residency

The University of Chicago Medicine
IL
Internship

New York University
NY
M.D.

University of Iowa
IA
Ph.D.

Insulin-like growth factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat.
Won L, Kraig RP. Insulin-like growth factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat. Brain Res. 2020 Apr 01; 1732:146673.
PMID: 31978377

IFN?-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression.
Pusic KM, Won L, Kraig RP, Pusic AD. IFN?-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression. Front Neurosci. 2019; 13:942.
PMID: 31551696

Intranasally administered IGF-1 inhibits spreading depression in vivo.
Grinberg YY, Zitzow LA, Kraig RP. Intranasally administered IGF-1 inhibits spreading depression in vivo. Brain Res. 2017 Dec 15; 1677:47-57.
PMID: 28951235

NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface.
Ochocinska MJ, Zlokovic BV, Searson PC, Crowder AT, Kraig RP, Ljubimova JY, Mainprize TG, Banks WA, Warren RQ, Kindzelski A, Timmer W, Liu CH. NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. Fluids Barriers CNS. 2017 May 01; 14(1):12.
PMID: 28457227

Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation.
Pusic KM, Pusic AD, Kraig RP. Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation. Cell Mol Neurobiol. 2016 Apr; 36(3):313-325.
PMID: 26993508

Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.
Quesenberry PJ, Aliotta J, Camussi G, Abdel-Mageed AB, Wen S, Goldberg L, Zhang HG, Tetta C, Franklin J, Coffey RJ, Danielson K, Subramanya V, Ghiran I, Das S, Chen CC, Pusic KM, Pusic AD, Chatterjee D, Kraig RP, Balaj L, Dooner M. Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:27575.
PMID: 26320942

Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression.
Pusic AD, Kraig RP. Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression. J Interferon Cytokine Res. 2015 Oct; 35(10):795-807.
PMID: 26083947

Spreading depression transiently disrupts myelin via interferon-gamma signaling.
Pusic AD, Mitchell HM, Kunkler PE, Klauer N, Kraig RP. Spreading depression transiently disrupts myelin via interferon-gamma signaling. Exp Neurol. 2015 Feb; 264:43-54.
PMID: 25500111

Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment.
Pusic KM, Pusic AD, Kemme J, Kraig RP. Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment. Glia. 2014 Jul; 62(7):1176-94.
PMID: 24723305

What are exosomes and how can they be used in multiple sclerosis therapy?
Pusic AD, Pusic KM, Kraig RP. What are exosomes and how can they be used in multiple sclerosis therapy? Expert Rev Neurother. 2014 Apr; 14(4):353-5.
PMID: 24552578

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