Dr Roos is the Marjorie and Robert E. Straus Professor in Neurological Science in the Department of Neurology. His research program is focused on the pathogenesis of neurodegenerative diseases, especially amyotrophic lateral sclerosis, and on investigations of picornavirus central nervous system infections. He has published more than 200 papers. Dr. Roos previously served as Chair of the Department of Neurology. He has been a member of the Editorial Boards of the J. Neuroimmunology, J. Neurovirology, J. Virology, and Annals of Neurology, and presently serves on the Editorial Board of Virology and Scientific Reports. He is Associate Editor of Neurology Genetics and Editor-in-Chief of MedLink (an on-line Neurology site). He is a member of the US FDA Cellular, Tissues and Gene Therapies Advisory Committee. He formerly served as Chair of the FDA Transmissible Spongiform Encephalopathies Committee as well as the Chair of the Vaccines and Related Biological Products Advisory Committee. He was a member of the National Academy of Sciences Institute of Medicine Committee to Examine Multiple Sclerosis, American Academy of Neurology Science Committee, Amyotrophic Lateral Sclerosis (ALS) Association grant review committee, National Multiple Sclerosis Society Research Programs Advisory Committee (which he Chaired), and NIH NINDS grant review study section.
University of California, Irvine
Irvine, CA
- Visiting Professor in poliovirus lab of Dr. Bert Semler
1989
University of Utah Medical Center
Salt Lake City, UT
- Visiting Professor in poliovirus lab of Dr. Ellie Ehrenfeld
1981
Johns Hopkins Hospital
Baltimore, MD
- Neurovirology and Neuroimmunology Post-doctoral fellowship
1976
Johns Hopkins Hospital
Baltimore, MD
- Neurology Residency
1974
NINDS, NIH
Bethesda, MD
- Slow Virus (prion) Laboratory of D.C. Gajdusek
1971
Kings County Hospital
Brooklyn, NYC, NY
- Internship in Medicine
1969
Columbia College
NYC, NY
AB - Chemistry, Premed
1964
SUNY, Downstate Medical Center
Brookly, NYC, NY
medicine - Medicine
1964
Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions.
Gleason AC, Ghadge G, Chen J, Sonobe Y, Roos RP. Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions. PLoS One. 2022; 17(6):e0256411.
PMID: 35648796
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Sonobe Y, Aburas J, Krishnan G, Fleming AC, Ghadge G, Islam P, Warren EC, Gu Y, Kankel MW, Brown AEX, Kiskinis E, Gendron TF, Gao FB, Roos RP, Kratsios P. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation. Nat Commun. 2021 10 15; 12(1):6025.
PMID: 34654821
Neurology: Genetics Year in Review.
Pulst S, Pandolfo M, Roos R, Milone M, Jayadev S. Neurology: Genetics Year in Review. Neurol Genet. 2021 Feb; 7(1):e556.
PMID: 33889725
RNA-binding protein altered expression and mislocalization in MS.
Masaki K, Sonobe Y, Ghadge G, Pytel P, Lépine P, Pernin F, Cui QL, Antel JP, Zandee S, Prat A, Roos RP. RNA-binding protein altered expression and mislocalization in MS. Neurol Neuroimmunol Neuroinflamm. 2020 05; 7(3).
PMID: 32217641
Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.
Ghadge GD, Sonobe Y, Camarena A, Drigotas C, Rigo F, Ling KK, Roos RP. Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS. Neurobiol Dis. 2020 03; 136:104702.
PMID: 31837419
2018: Year in Review and Message from the Editors to Our Reviewers.
Pulst SM, Roos RP, Durr A, Vance JM, Milone M, Pandolfo M. 2018: Year in Review and Message from the Editors to Our Reviewers. Neurol Genet. 2019 Feb; 5(1):e309.
PMID: 30842976
TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.
Masaki K, Sonobe Y, Ghadge G, Pytel P, Roos RP. TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection. PLoS Pathog. 2019 02; 15(2):e1007574.
PMID: 30742696
Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice.
Ghadge GD, Kay BK, Drigotas C, Roos RP. Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice. Neurobiol Dis. 2019 01; 121:131-137.
PMID: 30176351
Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress.
Sonobe Y, Ghadge G, Masaki K, Sendoel A, Fuchs E, Roos RP. Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress. Neurobiol Dis. 2018 08; 116:155-165.
PMID: 29792928
Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS.
Riehm JJ, Wang L, Ghadge G, Teng M, Correa AM, Marks JD, Roos RP, Allen MJ. Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS. Neurobiol Dis. 2018 07; 115:115-126.
PMID: 29627580
Dr. Frank L. Babbott, MD Memorial Award
SUNY Downstate
2018
Society for Scholars
Johns Hopkins Medical School
2006
Fellow in Medical Science
AAAS
2004