People

Wim Van Drongelen, PhD

Research Interests- Understanding mechanisms underlying Epilepsy



Epilepsy is a serious neurological disorder characterized by seizures. About 1% of the world population is affected by this disease and a fraction of 1/3 of patients does not respond to medication. In order to help us understand the pathological behavior we observe during the brain’s epileptiform activity, our group applies a variety of engineering techniques including advanced statistical and digital signal processing, non-linear dynamics, and modeling (link to basic texts) (link to second edition text). The ultimate goal of the research in our lab is to address this enormous problem by improved understanding of the mechanisms that govern different types of epilepsy.



See the lab website for further details, teaching, and videos on lectures



Our research approach is interdisciplinary, including:

Mathematical modeling

Computational modeling

Animal models

Study of tissue from patients with epilepsy

Analysis of clinical recordings

Role of paroxysmal depolarization in focal seizure activity.
Tryba AK, Merricks EM, Lee S, Pham T, Cho S, Nordli DR, Eissa TL, Goodman RR, McKhann GM, Emerson RG, Schevon CA, van Drongelen W. Role of paroxysmal depolarization in focal seizure activity. J Neurophysiol. 2019 Nov 01; 122(5):1861-1873.
PMID: 31461373

DC shifts, high frequency oscillations, ripples and fast ripples in relation to the seizure onset zone.
Lee S, Issa NP, Rose S, Tao JX, Warnke PC, Towle VL, van Drongelen W, Wu S. DC shifts, high frequency oscillations, ripples and fast ripples in relation to the seizure onset zone. Seizure. 2019 May 03.
PMID: 31101405

Reply to "which small sharp spikes are benign epileptiform transients of sleep?"
Issa NP, Lee S, Wu S, Rose S, Towle VL, Warnke PC, van Drongelen W, Tao JX. Reply to "which small sharp spikes are benign epileptiform transients of sleep?" Clin Neurophysiol. 2018 11; 129(11):2495-2496.
PMID: 30268708

A glimpse into the future of clinical neurophysiology: Can we use machines to interpret EEG?
Smith G, Lee S, van Drongelen W. A glimpse into the future of clinical neurophysiology: Can we use machines to interpret EEG? Clin Neurophysiol. 2018 10; 129(10):2186-2187.
PMID: 30087004

The Relationship Between Ictal Multi-Unit Activity and the Electrocorticogram.
Eissa TL, Schevon CA, Emerson RG, Mckhann GM, Goodman RR, Van Drongelen W. The Relationship Between Ictal Multi-Unit Activity and the Electrocorticogram. Int J Neural Syst. 2018 Dec; 28(10):1850027.
PMID: 30001641

Cross-scale effects of neural interactions during human neocortical seizure activity.
Eissa TL, Dijkstra K, Brune C, Emerson RG, van Putten MJAM, Goodman RR, McKhann GM, Schevon CA, van Drongelen W, van Gils SA. Cross-scale effects of neural interactions during human neocortical seizure activity. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):10761-10766.
PMID: 28923948

Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex.
Eissa TL, Tryba AK, Marcuccilli CJ, Ben-Mabrouk F, Smith EH, Lew SM, Goodman RR, McKhann GM, Frim DM, Pesce LL, Kohrman MH, Emerson RG, Schevon CA, van Drongelen W. Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex. eNeuro. 2016 Mar-Apr; 3(2).
PMID: 27257623

Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents.
Suresh J, Radojicic M, Pesce LL, Bhansali A, Wang J, Tryba AK, Marks JD, van Drongelen W. Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents. J Neurophysiol. 2016 06 01; 115(6):3073-89.
PMID: 26984425

Wilson-Cowan Equations for Neocortical Dynamics.
Cowan JD, Neuman J, van Drongelen W. Wilson-Cowan Equations for Neocortical Dynamics. J Math Neurosci. 2016 Dec; 6(1):1.
PMID: 26728012

Modeling focal epileptic activity in the Wilson-cowan model with depolarization block.
Meijer HG, Eissa TL, Kiewiet B, Neuman JF, Schevon CA, Emerson RG, Goodman RR, McKhann GM, Marcuccilli CJ, Tryba AK, Cowan JD, van Gils SA, van Drongelen W. Modeling focal epileptic activity in the Wilson-cowan model with depolarization block. J Math Neurosci. 2015; 5:7.
PMID: 25852982

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