Raymond Roos, MD

Marjorie and Robert E. Straus Professor in Neurologic Science
Associate Chair for Education
Director, ALS Clinic
Co-Director, The Center for Peripheral Neuropathy

Patient Calls: 773-702-6222
Fax: 773-702-9076

Raymond P. Roos, MD, is an established expert on neurodegenerative diseases (such as ALS and prion diseases), multiple sclerosis (MS), and neuropathy.

He co-directs the Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease clinic. He also sees patient with other neurological problems, such as MS neurodegenerative diseases (e.g., Creutzfeldt-Jakob disease), and inflammatory central nervous system diseases.

A basic goal of Dr. Roos' research studies is to use molecular techniques to better understand the pathogenesis of MS and ALS. For instance, in one investigation, he and his colleagues sought to identify genes and gene products critical to the death and survival of motor neurons--especially as related to neurodegenerative diseases such as ALS. The lab uses viruses and transgenic mouse models in order to clarify the mechanisms by which mutant genes kill the target neurons.

Education & Training
  • Visiting Scientist: Department of Microbiology and Molecular Genetics, University of California
  • Research Associate: Department of Cellular, Viral and Molecular Biology, University of Utah Medical Center
  • Fellowship: Johns Hopkins School of Medicine
  • Residency: Johns Hopkins Hospital
  • Staff Associate: Special Chronic Diseases Study Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD
  • Internship: State University of New York, Kings County Hospital
  • M.D.: State University of New York, Downstate Medical School
  • A.B.: Columbia College
Board Certification
  • Neurology, American Board of Psychiatry and Neurology
Clinical Interests
  • Neurology
  • Amyotrophic lateral sclerosis (ALS)
  • Neurodegenerative disease
  • Multiple sclerosis (MS)
  • CNS inflammatory diseases
  • Neuropathy
Research Interests
  • Delineate genes and gene products critical to the death and survival of neurons, especially related to neurodegenerative diseases such as amyotrophic lateral sclerosis.
  • Investigate disease induced by picornaviruses (poliovirus and Theiler's virus) in order to identify molecular determinants for neurovirulence, virus persistence and demyelination, and the mechanisms involved. The identification of virus genes important in these phenotypes may not only clarify the pathogenesis of the virus diseases but also lead to an understanding of genes important in the normal CNS function and in human CNS disease states (such as amyotrophic lateral sclerosis and multiple sclerosis).
  • The pathogenesis of ALS
  • Unconventional virus infections of the CNS, such as prion diseases
  • Virus models of motor neuron disease and immune-mediated demyelinating disease (e.g., Theiler's virus)
  • Mouse models of CNS diseases (e.g., transgenic mouse models)
  • MS
  • Picornaviruses
  • Director, weekly Roos Rounds
Society Memberships
  • American Academy of Neurology
  • American Neurological Association
  • American Society for Virology
  • Society for Neuroscience
Selected Publications