Multiple Sclerosis Fellowship

Program Overview

The multiple sclerosis fellowship is tailored to the applicant's interests. Potential fellowships are:

  1. One-year clinically oriented fellowship;
  2. Two-year clinical care/clinical trial fellowship; and
  3. Two-years of laboratory research on the immunology, molecular biology, and genetics of MS, or on novel immune-based therapeutic agents and gene knockout models in EAE and brain myelination.

Educational Goals & Objectives

To become an expert in diagnosis and treatment of MS and to have profound insight into the cause and mechanisms of the disease.

For clinical fellowships – Excellence in clinical exam in MS; clinical trial design, biostatistics, and the function of clinical trials.

For research/clinical fellowships – Mastering the above criteria, plus clinical or bench research that will depend on the applicant’s preferences. Current faculty interests and mentoring include a broad spectrum of basic science and translational research. These include the immunology of MS, interferon responses in immune cells, gene expression in MS and related diseases, pharmacogenetics, basic and clinical mechanism of action of most current therapies, fingolimod effects on immune cells and peripheral nerves, molecular biology of oligodendroglia. More translational studies include investigation of the clinical and immune overlap with MS variants such as neuromyelitis optica and CNS Sjögren’s syndrome, longevity from drug therapy, clinical effects of estrogens and vitamin D, OCT evaluation of MS and MS variants during drug therapy, and advanced MRI techniques for evaluating specific brain regions and pathways.

Supervisory Guidelines

Fellows are supervised by faculty with extensive clinical, clinical trial, and basic research expertise in MS. MS patients and clinical trials MS patients are seen in a busy clinic five days per week.

Approximately 10 clinical trials are ongoing to investigate the benefit and mechanisms of experimental new drugs for the treatment of MS and its symptoms.

An internationally-known group of translational and basic science faculty researchers are investigating the immunology and electrophysiology of MS, novel therapeutic compounds, myelin formation and its genetic and neurotrophic control, and brain protein and virus-induced EAE.