John Ebersole, MD

Director, Adult Epilepsy Service
Director, Clinical Neurophysiology Program
Medical Director, Illinois MEG Center
Editor-in-Chief, Journal of Clinical Neurophysiology

Assistant: Debbie Greusel
Telephone: 773-834-4703
Patient Calls: 773-834-4703
Fax: 773-834-4800
Email: Direct:

An internationally recognized authority on epilepsy and electroencephalography, John Ebersole, MD, is an expert in seizure disorders that are difficult to understand or control. He spearheaded the combined use of functional data from EEG with structural data from brain MRI in order to diagnose and localize epilepsy better. Over the past 10 years, research from his laboratory has led to the development of 3-D models of epileptic foci in the brain, which enable our doctors to pinpoint the sources of seizures.

As director of the University of Chicago Adult Epilepsy Center, Dr. Ebersole oversees the medical campus's Epilepsy Monitoring Unit. Here the EEG and behavior of adult patients are continuously recorded for several days in order to diagnose, characterize, classify, and localize their seizures.

Dr. Ebersole is actively involved in the education of today's and tomorrow's neurologists. He is editor-in-chief of the Journal of Clinical Neurophysiology and co-editor of the textbook, Current Practice of Clinical Electroencephalography, Third Edition.

Education & Training
  • Fellowship: National Institute of Neurological Disorders and Stroke, National Institutes of Health
  • Fellowship: National Hospital, London
  • Residency: Yale University School of Medicine
  • Internship: University of California, San Diego
  • M.D.: Yale University School of Medicine
Board Certification
  • Neurology, American Board of Psychiatry & Neurology
  • Clinical Neurophysiology, American Board of Clinical Neurophysiology
Clinical Interests
  • The diagnosis and treatment of seizure disorders that have been difficult to understand or control with standard antiepileptic medications are the principal interests of Dr. Ebersole. Although he specializes in the evaluation of patients with uncontrolled seizures for possible surgical therapy, he is equally interested in diagnostic and classification problems and treatment with the most up-to-date medications. Dr. Ebersole oversees the operation of the Epilepsy Monitoring Unit where the EEG and video of patients can be recorded continuously for several days in order to characterize their seizures and localize the origin within the brain. Dr. Ebersole sees new patients weekly in clinics at the Center for Advanced Medicine.
Research Interests
  • Dr. Ebersole's clinical research program is aimed at developing and validating computer-based techniques of functional imaging and localization using scalp and intracranial EEG. Over the past ten years research from his laboratory has established the usefulness of spike and seizure source modeling with both EEG and MEG in order to localize non-invasively epileptogenic foci in epilepsy surgery candidates. Ongoing projects include studies of dipole and extended source models of epileptic foci, development of realistic head and brain models for source computations, and co-registration of scalp and intracranial EEG onto 3-D MRI reconstructions of the head and brain, respectively.
  • Director, Clinical Neurophysiology Fellowship Program
Society Memberships
  • American Academy of Neurology
  • American Board of Clinical Neurophysiology
  • American Clinical Neurophysiology Society
  • American Epilepsy Society
Selected Publications