Roos, Raymond P., MD

Marjorie and Robert E. Straus Professor in Neurologic Science
Associate Chair for Education
Director, ALS Clinic
Co-Director, Jack Miller Center for Peripheral Neuropathy

Address: 5841 S. Maryland Ave., MC 2030
Chicago, IL 60637-1470
Telephone: 773-702-5659
Secretary: Melissa Meskers
Patient Calls: 773-702-7852
Fax: 773-702-9076
Education & Training
  • A.B., 1964, Columbia College
  • M.D., 1968, State University of New York, Downstate Medical School
  • Internship (Straight Medicine), 1968-1969, State University of New York, Kings County Hospital, Brooklyn, NY
  • Staff Associate, 1969-1971, Special Chronic Diseases Study Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD
  • Residency (Neurology), 1971-1974, The Johns Hopkins Hospital, Baltimore, MD
  • Fellowship (Neurovirology and Immunology), 1974-1976, The Johns Hopkins School of Medicine, Baltimore, MD
  • Research Associate, Visiting Professor, 1980-1981, Department of Cellular, Viral and Molecular Biology, University of Utah Medical Center, Salt Lake City, UT
  • Visiting Scientist, 1988-1989, Department of Microbiology and Molecular Genetics, University of California - Irvine, Irvine, CA
  • Board Certified, American Board of Psychiatry and Neurology, 1976
Clinical Interests
  • Amyotrophic Lateral Sclerosis (ALS)
  • Multiple Sclerosis (MS)
  • Peripheral Neuropathy
  • CNS Viral Infections
  • Prion Diseases
Research Interests
  • The pathogenesis of ALS
  • Unconventional virus infections of the CNS, such as prion diseases
  • Virus models of motor neuron disease and immune-mediated demyelinating disease (e.g., Theiler’s virus)
  • Mouse models of CNS diseases (e.g., transgenic mouse models)
  • MS
  • Picornaviruses
  • Investigate disease induced by picornaviruses (poliovirus and Theiler’s virus) in order to identify molecular determinants for neurovirulence, virus persistence and demyelination, and the mechanisms involved. The identification of virus genes important in these phenotypes may not only clarify the pathogenesis of the virus diseases but also lead to an understanding of genes important in the normal CNS function and in human CNS disease states (such as amyotrophic lateral sclerosis and multiple sclerosis).
  • Delineate genes and gene products critical to the death and survival of neurons, especially related to neurodegenerative diseases such as amyotrophic lateral sclerosis.
Selected Publications
  1. Baida, G., Popko, B., Wollmann, R.L., Tretiakova, M, Krausz, T.N., Roos, R.P. A subgenomic segment of Theiler’s Murine Encephalomyelitis virus RNA causes peripheral nerve demyelination. Submitted.
  2. Pallansch, M.A. and Roos, R.P. Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses, and Newer Enteroviruses. Fields’ Virology. (Ed. Knipe, D.N. and Howley, P.M.) 5th Edition, in press.
  3. Ghadge, G.D., Wang, L., Sharma, K., Monti, A.L., Bindokas, V., Stevens, F.J., Roos, R.P. Truncated wild-type superoxide dismutase type 1 (SOD1) and familial amyotrophic lateral sclerosis-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord. Neurobiol. Dis. 21(1) 194-205, 2006.
  4. Guest, S. and Roos, R.P. Molecular Determinants of TMEV pathogenesis. Experimental Models of Multiple Sclerosis. (Ed. Lavi, E. and Constantinescu, C.S.) Springer, 2005.
  5. Guest, S., Pilipenko, E., Sharma, K., Chumakov, K., and Roos, R.P. Molecular mechanisms of attenuation of Sabin strain of poliovirus 3. J. Virol. 78(20):11097-107, 2004.
  6. Nix, W.A., Berger, M.M., Oberste, M.S., Brooks, B.R., McKenna-Yasek, D., Brown, R.H., Roos, R.P., and Pallansch, M.A. Failure to detect enterovirus in the spinal cord of ALS patients using a sensitive RT-PCR method. Neurology 62 (8):1372-1377, 2004.
  7. Lin, X., Ma, X., Rodriguez, M., and Roos, R.P. CD4 cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J Mice. Int. Immunol. 16(9):1237-40, 2004.
  8. Rezania, K., Yan, J., Dellefave, L., Deng, H.-X., Siddique, N., Pascuzzi , R.T., Siddique, T., and Roos, R.P. A Novel Cu/Zn superoxide dismutase-1 mutation causing familial amyotrophic lateral sclerosis with variable age of onset, incomplete penetrance and a sensory neuropathy. ALS and other MNDs J. 4:162-166, 2003.
  9. Ghadge, G.D., Slusher, B.S., Bodner, A., Dal Canto, M.,Wozniak, K., Thomas, A., Rojas, C., Tsukamoto, T., Majer, P., Miller, R.J., Monti, A.L., and Roos, R.P. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial ALS (FALS) models. Proc. Natl. Acad. Sci. 100:9554-9559, 2003.
  10. Lin, X., Ma, X., Rodriguez, M., Feng, X., Zoecklein, L., Fu, Y.X., and Roos, R.P. Membrane lymphotoxin is required for resistance to Theiler’s virus infection and demyelination. Int. Immunol. 15 (8):955-962, 2003.
  11. Roos, R.P. Book Review - How the Cows turned Mad (by Maxime Schwartz). N Eng J Med. 348 (26):2695-2696, 2003.
  12. Mastrianni, J. and Roos, R.P. Wrinkles and Folds of the Prion Protein. Neurology 61:1168-1169, 2003.
Back to Top