Brorson, James, MD

Associate Professor
Director, Neurology Medical Student Clerkship Program

Address: 5841 S. Maryland Ave., MC 2030
Chicago, IL 60637-1470
Telephone: 773-702-9439
Secretary: Jennifer Lowe
Patient Calls: 773-702-7215
Fax: 773-702-9076
Laboratory Website: Dr. Brorson's Laboratory
Education & Training
  • M.D, 1985, The University of Chicago
  • Residency (Neurology), 1986-1989, University of Pennsylvania
  • Research Fellowship (Departments of Neurology and Pharmacological and Physiological Sciences), 1989-1993, The University of Chicago
  • Board Certified in Neurology, American Board of Psychiatry and Neurology, October, 1991
Clinical Interests
  • Cerebrovascular disease
  • Neuroprotective treatment in acute stroke
  • Secondary stroke prevention
  • Moya-moya and other intracranial arterial occlusive diseases
Research Interests
  • Molecular physiology of AMPA receptors and their role in neurodegeneration
  • Hypoxia-inducible factor-1 and adaptive responses of neurons to hypoxia
  • Nitric oxide and its effects on mitochondrial physiology
  • Pathophysiology of reperfusion injury in stroke
Teaching
  • Medical Biology 307; Clinical Pathophysiology & Therapeutics: Section Coordinator, CNS diseases; lecturer on “Clinical Aspects of Stroke” 1994-present.
  • Medicine MEDC 69500 (Vignettes in Physiology): lecturer on ”Pathophysiology of Stroke” 2004-present.
  • Neurobiology 33100, “Neurobiology of Learning and Memory”; lecturer on ‘Glutamate receptor channel properties’ 2006.
Selected Publications
  1. Sean Ruland, D Richardson, E Hung, James R. Brorson, S Cruz-Flores, W L. Felton 3rd, G Ford-Lynch, Cathy Helgason, C Hsu, J Kramer, P Mitsias, Philip B. Gorelick, for the AAASPS Investigators. “Predictors of recurrent stroke in African Americans.” Neurology, 67:567-571; 2006.
  2. Dongdong Li, Jeremy D. Marks, Paul T. Schumacker, Regina M. Young, and James R. Brorson; “Physiological hypoxia promotes survival of cultured cortical neurons.” European Journal of Neuroscience, 22:1319-1326; 2005.
  3. Takeshi Suzuki, Yoshihiro Abe, Daniel S. McGehee, J. Russel Keath, Hiroshi Yajima, Kamal Sharma, and James R. Brorson; “Long-lived retrograde fluorescent labeling of corticospinal neurons in the living animal.” Brain Research Protocols, 13:183-188; 2004.
  4. James R. Brorson, Dongdong Li, and Takeshi Suzuki; “Selective heteromeric expression of AMPA receptors driven by flip/flop differences.” Journal of Neuroscience, 24:3461-3470; 2004.
  5. Wim Vandenberghe, Vytautas P. Bindokas, Richard J. Miller, Wim Robberecht, and James R. Brorson; “Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons.” European Journal of Neuroscience, 14:305-314; 2001.
  6. Wim Vandenberghe, Eva C. Ihle, Doris K. Patneau, Wim Robberecht, and James R. Brorson; “AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability.” Journal of Neuroscience, 20:7158-7166; 2000.
  7. Emin Maltepe, Brian Keith, Andrew M. Arsham, James R. Brorson, and M. Celeste Simon; “The role of ARNT2 in tumor angiogenesis and the neuronal response to hypoxia.” Biochemical and Biophysical Research Communications 273: 231-238; 2000.
  8. Wim Vandenberghe, Wim Robberecht, and James R. Brorson; “AMPA receptor calcium permeability, Glu receptor 2 expression, and selective motoneuron vulnerability.” Journal of Neuroscience, 20:123-132; 2000.
  9. James R. Brorson, Paul T. Schumacker, and He Zhang; “Nitric oxide acutely inhibits neuronal energy production.” Journal of Neuroscience, 19:147-158; 1999.
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