Soliven, Betty, MD

Associate Professor
Director, Electrodiagnostic Lab for Neuromuscular Disease
Co-Director, ALS Clinic

Address: 5841 S. Maryland Ave., MC 2030
Chicago, IL 60637-1470
Telephone: 773-702-6393
Secretary: Jennifer Lowe
Patient Calls: 773-702-6222
Fax: 773-702-9076
Education & Training
  • M.D. (1980), University of Santo Tomas
  • Residency (Neurology), 1982-1985, University of Chicago
  • Fellowship (EMG-Neuromuscular), 1985-1986, Columbia University Medical Center
  • Fellowship (Research fellowship in cellular physiology), 1986-1989, University of Chicago
  • Diplomate, Neurology, 1987
  • Diplomate, Electrodiagnostic Medicine, 1989
Clinical Interests
  • Inflammatory neuropathies, and other neuropathies
  • Myasthenia and Lambert-Eaton syndrome
  • Myopathies
  • ALS
Research Interests
  • Immunopathogenetic mechanisms and treatment of inflammatory neuropathies such as CIDP utilizing the animal model B7-2 deficient NOD mouse
  • Glial electrophysiology and biology, most recently focused on growth factors and lysosphingolipid receptors in Schwann cells and oligodendrocytes, which are cells that synthesize myelin in the PNS and CNS, respectively
  • Behavioral and electrophysiologic characterization of other animal models of neuropathy.
Teaching
  • lectures on neuromuscular diseases and electromyography (residents’ lecture series, and neurophysiology fellows’ lecture series)
  • monthly Neuromuscular Pathology Conference
  • training in the performance and interpretation of nerve conduction studies and electromyography
  • CPP course: Neuromuscular disease
  • Neurobiology of Disease Course-neuromuscular section
Selected Publications
  1. Gilbert SL, Zhang L, Forster M, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson, MT, Wollmann RL, Lahn BT. 2006. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nature Genetics 2006 Feb;38(2):245-50.
  2. Rezania K, Arnason BG, Soliven B. 2006. Patterns and significance of concomitant central and peripheral inflammatory demyelination. Neurol Res 28:326-333.
  3. Levadakou, EN, Chen X-J, Soliven B, Popko B. 2005. Disruption of the mouse Large gene by the enr transgene results in a neuromuscular phenotype: evidence of dystroglycan requirement for agrin-MuSK signaling. Mol Cell Neurosci 28:757-769.
  4. Iwase, T, Jung, CG, Zhang, M, Bae H, Soliven B. 2005. GDNF-mediated signaling in Schwann cells. J. Neurochem 94 (6): 1488-1499.
  5. Bacia A, Wollmann R, Soliven B. 2004. K+ channel blockade impairs remyelination in the cuprizone model. Glia 48(2):156-65
  6. Rezania K, Gundogdu B and Soliven B. 2004. Pathogenesis of chronic inflammatory demyelinating polyneuropathy. Frontiers in Biosci 9: 939-945.
  7. Soliven B. 2004. Chronic inflammatory demyelinating polyradiculoneuropathy. Medlink Neurology (with biannual update).
  8. Soliven B, Ma L, Bae H, Attali B, Sobko A, Iwase T. 2003. PDGF upregulates the delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. Am J of Physiol (Cell Physiol) 284:C85-C93.
  9. Traka, M, Goutebouze L, Denisenko N, Nifli F, Havaki, S, Iwakura Y, Fukamauchi, F, Watanabe K, Soliven B, Girault JA, Karagogeos D. 2003 TAG-1 associates with Caspr-2 and is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J. Cell Biol. 162:1161-1172
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