Ebersole, John S., MD

Professor
Director, Adult Epilepsy Service
Co-Director, Comprehensive Epilepsy Center
Director, Clinical Neurophysiology Program
Chairman, Clinical Neurophysiology Section of the American Academy of Neurology

Address: 5841 S. Maryland Ave., MC 2030
Chicago, IL 60637-1470
Telephone: 773-834-4703
Secretary: TBD
Patient Calls: 773-834-4703
Fax: 773-702-9076
Education & Training
  • MD, Yale University School of Medicine
  • Internship, University of California, San Diego
  • Residency, Yale University School of Medicine
  • Fellowship, National Institute of Neurological Disorders and Stroke, National Institutes of Health
  • Fellowship, National Hospital, London
  • Board Certified, American Board of Psychology and Neurology
  • Board Certified, American Board of Clinical Neurophysiology
Clinical Interests
  • The diagnosis and treatment of seizure disorders that have been difficult to understand or control with standard antiepileptic medications are the principal interests of Dr. Ebersole. Although he specializes in the evaluation of patients with uncontrolled seizures for possible surgical therapy, he is equally interested in diagnostic and classification problems and treatment with the most up-to-date medications. Dr. Ebersole oversees the operation of the Epilepsy Monitoring Unit where the EEG and video of patients can be recorded continuously for several days in order to characterize their seizures and localize the origin within the brain. Dr. Ebersole sees new patients weekly in clinics at the Center for Advanced Medicine.
Research Interests
  • Dr. Ebersole’s clinical research program is aimed at developing and validating computer-based techniques of functional imaging and localization using scalp and intracranial EEG. Over the past ten years research from his laboratory has established the usefulness of spike and seizure source modeling with both EEG and MEG in order to localize non-invasively epileptogenic foci in epilepsy surgery candidates. Ongoing projects include studies of dipole and extended source models of epileptic foci, development of realistic head and brain models for source computations, and co-registration of scalp and intracranial EEG onto 3-D MRI reconstructions of the head and brain, respectively.
Society Memberships
  • American Academy of Neurology
  • American Board of Clinical Neurophysiology
  • American Clinical Neurophysiology Society
  • American Epilepsy Society
Selected Publications
  1. Ebersole JS. Ambulatory electroencephalographic monitoring. In: Aminoff MJ, ed. Electrodiagnosis in Clinical Neurology, 5th Edition, New York: Churchill Livingstone, 2005, in press.
  2. Ebersole JS. In search of seizure prediction: a critique. Clin Neurophysiol. 2005 Mar;116(3):489-92.
  3. Tao JX, Ray A, Hawes-Ebersole S, Ebersole JS. Intracranial EEG substrates of scalp EEG interictal spikes. Epilepsia. 2005 May;46(5):669-76.
  4. Ebersole JS. EEG dipole analysis. In: Rosenow F, Luders HO, eds. Handbook of Clinical Neurophysiology. Vol. 3: Pre-surgical Assessment of the Epilepsies with Clinical Neurophysiology and Functional Imaging, Elsevier, Amsterdam, pp. 471-490, 2004.
  5. Ebersole JS. Cortical generators of EEG. In: Burgess R, ed. Fundamaentals of EEG Technology, Second Edition, Lippincott, Williams and Wilkins, Philadelphia, pp. 35-47, 2004.
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